2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113438
    15(S)-HPETE
    15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies.
    15(S)-HPETE
  • HY-10873
    N-Desethyl Sunitinib
    		99.90%
    N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.
    N-Desethyl Sunitinib
  • HY-147323
    Ferulic acid 4-O-sulfate
    		98.07%
    Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) is a metabolite of Ferulic acid (HY-N0060). Ferulic acid 4-O-sulfate relaxes arteries and lowers blood pressure in mice.
    Ferulic acid 4-O-sulfate
  • HY-136650A
    Fludarabine triphosphate trisodium
    		99.98%
    Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
    Fludarabine triphosphate trisodium
  • HY-N7080
    Dihydroferulic acid
    		99.50%
    Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid.
    Dihydroferulic acid
  • HY-G0017
    N-Desmethyl imatinib
    		98.33%
    N-Desmethyl imatinib (Norimatinib) is a c-Abl tyrosine kinase inhibitor. N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways, and inhibits c-Abl-related neurodegenerative activity and neuroinflammation in vitro. N-Desmethyl imatinib can be used to study neurodegenerative diseases (such as Parkinson's disease).
    N-Desmethyl imatinib
  • HY-W011956
    6-Hydroxymelatonin
    		99.81%
    6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.
    6-Hydroxymelatonin
  • HY-76801
    24, 25-Dihydroxy VD2
    		99.89%
    24,25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2) is a hydroxylated metabolite and derivative of Vitamin D2 HY-76542 (HY-76542).
    24, 25-Dihydroxy VD2
  • HY-125348
    6α-Hydroxy paclitaxel
    		99.93%
    6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer.
    6α-Hydroxy paclitaxel
  • HY-70002B
    Enzalutamide carboxylic acid
    		98.11%
    Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist.
    Enzalutamide carboxylic acid
  • HY-B1786
    Sulindac sulfide
    		98.60%
    Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
    Sulindac sulfide
  • HY-135391
    Ezetimibe phenoxy glucuronide
    		99.77%
    Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.
    Ezetimibe phenoxy glucuronide
  • HY-W008449
    1-Methylxanthine
    		98.94%
    1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
    1-Methylxanthine
  • HY-W015590
    2-Hydroxyphenylacetic acid
    		98.79%
    2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, and is also a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid can be used as a potential biomarker for food. 2-Hydroxyphenylacetic acid can be used in the study of phenylketonuria and related hyperphenylalaninemias.
    2-Hydroxyphenylacetic acid
  • HY-B1180
    Vinburnine
    		99.78%
    Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.
    Vinburnine
  • HY-12784A
    Cycloguanil hydrochloride
    		99.93%
    Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil hydrochloride
  • HY-18719B
    Endoxifen hydrochloride
    		98.04%
    Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer study.
    Endoxifen hydrochloride
  • HY-N7143
    Monobutyl phthalate
    		99.72%
    Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant.
    Monobutyl phthalate
  • HY-W015169
    5-Methoxytryptamine
    		99.91%
    5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action.
    5-Methoxytryptamine
  • HY-113289
    Brassicasterol
    		98.71%
    Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC50=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease.
    Brassicasterol
Cat. No. Product Name / Synonyms Application Reactivity